Mind the Gap

M ake sure your trial is registered prospectively. (Trial registration)

I s your trial properly randomized? (Sequence generation)

N ecessary to conceal allocation. (Allocation concealment)

D oes anyone know the group assignments? (Blinding)

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G ive all your data (Incomplete outcome data)

A re you missing any outcomes? (Selective outcome reporting)

P otential other sources of bias? (Other sources of bias)